Abstract
FATCO syndrome (Fibular Aplasia, Tibial Camptomelia, Oligosyndactyly) is characterized by the presence of Fibula Aplasia, Tibial Campomelia and Oligosyndactyly. It is an autosomal dominant congenital genetic disorder, with an infrequent occurrence. This is the main reason behind the limited number of studies carried out to date, and the importance of carrying out this review to enhance the understanding of this syndrome. The objective of this review based on case reports is to describe and analyze the clinical and radiological characteristics of patients diagnosed with FATCO syndrome, in addition to demographic characteristics and concomitant anomalies. The databases used in this review were PubMed (Medline), Scopus, WOS, Google Scholar, Scielo and VHL Regional Portal. From the total number of studies, 35 studies were selected based on the inclusion criteria, which contained 59 clinical cases. The results of this review allowed us to identify that 70.4% of the population was male, of which 24.6% of the patients were from Peru. The clinical characteristics associated with this syndrome were syndactyly in the hands, tibia hypoplasia, presence of dimples in legs, tarsal bone dysplasia, congenital heart disease and esophageal atresia.
Recommended Citation
Dongo Cornejo, D’karlo Yosue; Gutiérrez Baca, Wendy Alessandra; Laso Salazar, Maria Cristina; and Abarca-Barriga, Hugo Hernán
(2025)
"Systematic Review About Clinical and Radiologic Manifestations in Patients with FATCO Syndrome,"
Journal of Pediatric Genetics: Vol. 14:
Iss.
1, Article 4.
Available at:
https://jpg.researchcommons.org/journal/vol14/iss1/4
JPG_4_Supplementary 2.xlsx (1625 kB)
JPG_4_Supplementary 3.xlsx (92 kB)